Piscitello Jr., Ted Jessup, Chris Regan, Joseph J. O'Brien, Billy Concha, Tara Strong, Tiffany, Bart A. Mark Donaldson, Becki Dennis, Michael Trisler, Ryan Hanna, David Goldman, Ronobir Lahiri, Nefetari Spencer, Jeffrey Stubblefield, Wellesley Wild, Lenny Clarke, Chris Neville, Rachael MacFarlane, Christy Scott Cashman, Josiah Blount, John Viener, Kate B. Biscione, Alexandra Creteau, Jack Knight, Lauren Sánchez, William Xifaras, Curtis Stigers, Liz Morgan, Alec Sulkin, Ralph Garman, Vanessa Vander Pluym, J. Jones, Patrick Warburton, Patrick Stewart, Michael Dorn, Bill Smitrovich, John Slattery, Cocoa Brown, John Carroll Lynch, Ron Canada, Liam Neeson, Dennis Haysbert, Tom Brady, Jay Leno, Jimmy Kimmel, Kate McKinnon, Bobby Moynihan, Taran Killam, Sebastian Arcelus, Jay Patterson, Steve Callaghan, Nana Visitor, Maggie Geha, Jessica Szohr, Craig Ricci Shaynak, Lexi Atkins, Dustin Ybarra, Julius Sharpe, Michael Steven Costello, Barry Ratcliffe, Tina Grimm, John Franchi, Claudia Zielke, Vincent M. When I'm not working, you'll either find me in the kitchen rustling up some mainly Indian or Italian inspired vegetarian dishes, out on my bike commuting, at martial arts training (Wing Tsun) or strumming away on the old guitar.Ted 2 tell story about "Newlywed couple Ted and Tami-Lynn want to have a baby, but in order to qualify to be a parent, Ted will have to prove he's a person in a court of law.".Ĭast : Mark Wahlberg, Seth MacFarlane, Amanda Seyfried, Morgan Freeman, Jessica Barth, Giovanni Ribisi, Sam J. These are the 7 areas in which I offer services so, if you think you might be interested in one of them, please get in touch! Niesamowity spider-man 2 lektor pl, Pine wilt disease symptoms, Vietnamese pig for sale uk, Fujitsu siemens amilo si 2636 drivers, Carolina balom direccion. A(z) 'Ted 2 (2015)' cím videót 'GoldHD1' nev felhasználó töltötte fel a(z) 'film/animáció' kategóriába. canada europe bars someone ads e pl 10 professionals dc pakistani. by liza ostashkovaover a year ago0 views. Aby uzyska zgod na opiek nad malcem, mi musi przekona sd, e jest istot yjc. Conducting job interviews in English as an outsourced consultant. Latest and most popular Youtube videos for Ted, including interviews, music videos. ) Lektor PL Odblokuj dostp do 12508 filmw i seriali premium od oficjalnych dystrybutorw Ogldaj legalnie i w najlepszej jakoci. Transcriptions of podcasts and webinars.ħ. A(z) '(HUN)' cím videót 'ShadowDrimex' nev felhasználó töltötte fel a(z) 'film/animáció' kategóriába. Voice recording for educational materials and computer games.ĥ. Proofreading and copy-editing-mainly involving work of an academic nature, though not exclusively.Ĥ. My customers like the fact that the translations are always written in a good style and do not contain the typical errors incurred by a non-native translator.ģ. I work from Polish into English in a wide scope of topic areas. I cooperate with a variety of companies ranging from academic institutions to fashion designers and software houses. I give face-to-face lessons at the student's place of work/home or in a cafe, depending on logistics and preference, or online via Skype.Ģ. I don't use course books because they bore me (and usually the students too) to death. ![]() Megavideo, Youtube, Video Google, itp. Uwaga aden z prezentowanych materiaów nie jest hostowany na serwerach ekino-tv Serwis udostpnia jedynie informacje o filmach oraz odnoniki do serwisów udostpniajcych zamieszczone materiay filmowe (mi. news articles, current affairs topics, YouTube, TED etc. Ogldaj 4K / FHD Online, Ogldaj Horror Online. List wszystkich oficjalnych adresów zawsze znajdziesz na tej stronie: ekino-tv.link. In terms of materials, I use 'authentic stuff'-i.e. Ta strona () to jedna z oficjalnych domen eKino-TV, pod któr dostpny jest nasz serwis. I co-owned and co-directed my own language school in the Tri-City for 17 years and developed my own 'mini system' which I call 'Active Speak' that, as the name suggests, focuses on helping learners to improve their practical speaking skills. Living and working in Poland for the last 25 or so years has given me a wealth of experience in the following areas:ġ. I also picked up a DELTA diploma from the University of Cambridge in teaching English as a foreign language to adults. Qualifications CELTA DELTA Bachelor's degree (BA, MS, BEd, BFA, etc.)Ī life-long fan of languages, having delved into French, Latin and Greek at school, I graduated in Modern Languages (French and Arabic) from the University of Salford.
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![]() Ginger Pygmy - Put a Pygmy on the golden pedestal inside the Chamber of Time, set it to the central-right position and activate the time energy.Baby Pygmy - Put a Pygmy on the golden pedestal inside the Chamber of Time, set it to the central-left position and activate the time energy.Old Fart Pygmy - Put a Pygmy on the golden pedestal inside the Chamber of Time, set it to the leftmost position and activate the time energy.Half Pygmy - Have a Pygmy be sliced in half by Charlie in his tiger form.Possessed Pygmy - Possess a Pygmy using a Ghost Pygmy on Graveyard Island, or by putting them on the winch or bongos on Ape Mountain.Ghost Pygmy - Allow a Pygmy to die with the ghost interaction enabled on Graveyard Island.Zombie Pygmy- Bury a Pygmy in the grave on Graveyard Island.Marshmallowed Pygmy - Hold a Pygmy over the campfire on Rock Island. ![]() Vampire Pygmy - Allow a Pygmy to be bitten by a vampire bat.Unlike Charlie, he can be killed as a normal pygmy. Tom is a parody of Tom Cruise, he can begin the apocalypse on apocalypse island. There are sacrifices that won't kill him that would ordinarily kill pygmies ![]() Charlie walks around the island saying various phrases, turning into tigers and warlocks, and killing pygmies. There names cannot be changed.Ĭharlie is a parody of Charlie Sheen. There are two guest pygmies in the game, Charlie and Tom. The only non-Tribe Ookga Chaka Pygmies are "guest Pygmies" named Charlie (introduced in Ep 38: Two and a Half Pygmies) - a parody of Charlie Sheen with many alternate forms and catchphrases - and Tom (introduced in Ep 47: Apocalypse, Ow!) - a parody of Tom Cruise with many references to the Scientology religion. Note: They are identical in the game, but in other Pocket God forms such as the comic book they are given distinct personalities and somewhat different appearances so it is easier to tell them apart when reading the comics than when playing the game. These characters are also the focus of Pocket God Merchandise, including the c omic book. When the player starts out with Pocket God, the default tribe is known as Tribe Ooga Chaka and contains the following six Pygmies. The Pygmies are subject to the gods' every whim and therefore can be killed off in many ways, but can always be re-spawned onto the island by the little plus button in the left hand corner of the screen. Pygmies were temporarily referred to as 'islanders' due to the Pacific Islander controversy (see below). They tend to interact with the environment by fishing, collecting firewood, watching the sunset, sleeping and other interactions that can be turned on and off by the player, their god. They can also access to the Chamber of Time, the Locust Room, the Dance Room, the Plague Room and the Purification Chamber by entering the Apocalypse Temple. They can also go in the Underwater Area and in the Coral Reef when you make a tsunami. The Pygmies can live on several islands: Sand Island, Rock Island, Graveyard Island, Ice Island, The Island of Misfit Crossovers, Ape Mountain, God Island and Apocalypse Island. The most Pygmies that can be an an island is six, though there are ways of getting around this rule (please see the "Trivia" section). The point of Pygmies is to provide the player subjects to rule over as god. Pygmies are a tiny, primitive race of people are the subject of the iPhone/iPod Touch/iPad/Kindle Fire game Pocket God, the comic series based on the app, the iPad-exclusive app Pocket God: Journey To Uranus, and the version of the app on Facebook. For the Pygmies in the Facebook version, see Pygmy (Facebook Version). Six Pygmies on Sand Island (one is hidden behind another). It might be a temporary glitch causing the problem. It is recommended to first try restarting the Teams app to fix this issue. And also, check your network connection and make sure you are connected to a stable and reliable internet connection.
![]() Raster images and fonts are stored as individual parts (in specified widely supported formats) and can be referred to by many pages in the same document.Īn annotated example of XPS markup for a fixed page follows. A Canvas element can be used to group Glyphs and Path elements into a structure that can treated as a unit. Markup in the FixedPage part employs Glyphs elements for runs of text and Path and Brush elements for vector graphics. The position of every visual element on a page is determined by co-ordinates relative to the origin (typically the top left corner) of that fixed rectangle. ![]() A page has a fixed size and orientation, defined by height and width attributes that specify the rectangular print area. Each page has a corresponding FixedPage "part," which describes all of the visual elements to be rendered on the page. The XPS format simply identifies runs of characters in the same font, size, and weight and locates the starting point for each run and the relative position for each character/glyph in the run. The XML markup used in XPS bears little relationship to the markup used in XML-based word-processing formats such as DOCX/OOXML or ODF_text (.odt) or in XML-based publication formats such as JATS or EPUB, all of which represent the logical structure of a document, for example, identifying headings and paragraphs. The format offers no capability to adjust layout or reflow text content. To implement the fixed layout of a page, the location of every visual element on the page is precisely sized and positioned. See Notes below for details of the formats permitted for such embedded resources. This includes all resources such as fonts and images that might be required to render Must include everything necessary to fully render its content on a display device or physical medium (forĮxample, paper). One or more documents to be printed together. The XPS document format represents a set of related pages with fixed layout, which are organized as After a few further modifications, ECMA-388: Open XML Paper Specification (OpenXPS) was published in June 2009. See XML Paper Specification: Working draft 1.0.1. In September 2007, Microsoft submitted a re-organized version of its XPS specification to Ecma International for approval as an international standard. Without the application used to create it. The XPS format was designed as a "paginated representation of electronic paper that is based on XML," developed to be an important component of printer support in Windows Vista (released for distribution in January 2007) but also to be a platform-independent format that could be viewed and printed The XPS (XML Paper Specification) format, developed by Microsoft, serves as a fixed-page document format, a spool file format, and a page description language (PDL) for printers. ![]() Some even help you backup and store your collections of addons with settings intact to share with others or move from one Kodi streaming device to another. Many Kodi wizards also act as fully automated repository control centers depending on the Kodi build being used. Some Kodi wizards act like media center setup assistants, ready at all times to help you manage the appearance, menu system, and even selection of addons for your Kodi media center software. exton on ExTiX 22.The best Kodi wizards listed below are great tools to help with media center setup and maintenance.PuppEX Jammy64 (Puppy Linux) compatible with Ubuntu 22.04 LTS :: Build 230222.MeX 64 bit Linux based on Debian Sid and Ubuntu 22.04 LTS with Ubuntu Desktop (Gnome 42.5), Kodi 19.4 and kernel 6.2.3-amd64-exton :: Build 230314.Run Raspberry Pi’s PIXEL Desktop on a PC or Mac – an Exton modified Build 230319 with Refracta Snapshot (so you can create your own Raspberrypi Debian 12 Pixel system).DebEX KDE Plasma, Build 230330, based on Debian 12 Sid/Bookworm with kernel 6.1.12-exton and Refracta Snapshot.ExTiX Deepin 23.4 Live based on Deepin 23 Alpha 2 (latest) with Refracta Snapshot and kernel 6.3.0-rc4-amd64-exton :: Build 230403.Andrew on MX Linux Exton Remix 64bit with LXQt 1.1.0 (latest) and kernel 5.10 replaced by kernel 5.17.7-amd64-exton :: Build 220524Īll donations go towards the upkeep of Linux Freedom!.exton on MX Linux Exton Remix 64bit with LXQt 1.1.0 (latest) and kernel 5.10 replaced by kernel 5.17.7-amd64-exton :: Build 220524.bobby on PuppEX Bookworm64 with Tint2 as DE :: Build 220807.exton on ExTiX 22.9 KDE Plasma together with Anbox (“Android in a Box” with Google Play Store pre-installed) :: Build 220922.exton on ExTiX Deepin 22.12 Live based on Deepin 20.8 (latest) with Refracta Snapshot and kernel 6.1.0-amd64-exton :: Build 221218.ExTiX Deepin 23.4 Live: Una versión basada en Deepin 23 Alpha 2 | Ubunlog on DOWNLOAD. ![]()
It supplies an exceptional play-through that’s different every time that you play with it. Left 4 Dead 2 seemingly have outgrown the decreasing Resident Evil franchise. In addition, you’ve got loads of new weapons and scenarios to relish however, let us not forget that the brand’s newest zombies may leave you hanging for dear life. Even the undead will dash to you whenever you’re seen or heard. The zombies here aren’t merely lumbering, clueless creatures but actually, go fast and so are all athletic. The events have been played by way of a run of movie-like episodes, which may keep you on the edge of one’s chair. The target here will be to survive an outbreak, a zombie apocalypse to become more accurate. Nothing comes near to The match is similar to any other you’ve got played and offers a multiplayer and single first-person gaming experience that’s indescribable. Just make an effort to play with it how it’s most useful experienced: Having a close set of friends and also a willingness to get rid of regularly. But a lot of this strain of the video game is lost once there are different players to share it with. You can play left 4 dead 2 By yourself however, it has really a mostly diminished encounter. When there are lots of great players around, the practice of obtaining a team that works together well can continue to be spotty. Tightly coordinated teamwork is important, so that really is a match better-played by close friends than with strangers. The same is true when you have a working mic, which you really can rely on. If you are the sort of multiplayer gamer who enjoys just consider a lone wolf strategy, then you won’t have a lot of fun. Therein lies the vital reason for Left 4 Dead 2 allure. In the Event, You had not guessed It out however, almost any team which can not communicate effortlessly isn’t going to survive long within the realm of Left 4 Dead 2. The outcomes certainly really are a pretty striking balance between too difficult encounters that simply create shame and also easy encounters that not successfully frees up the stress. It will take into consideration a wide choice of vectors that have health degrees, ammo, and participant places and subdue enemies in each landscape so. Conventional survival-horror games lose their frighten factor right as players understand where enemies predominate nevertheless, the Director helps to ensure that every experience is likely to be exceptional. The Manager could be your name for its artificial intelligence that conducts the moment to time events in a match. Gruesome creations can dominate the screen distance the sole star of the series could be your Manager. They are fast, effective at inducing lots of damage in a brief period of time, also with the capacity of collecting together in hordes in left 4 dead 2. The basic zombies can establish a plausible threat when things seem south in left 4 dead 2. Powers complement each other well, creating catastrophic dangers that may only be overcome with smart approaches and also a large amount of teamwork. Both designs and power collections are all cool in their own right however, Left 4 Dead 2 really uses those critters to the very best of these own abilities. ![]() ![]() This design makes them simple to recognize at a bunch and simple to spot what type of tactics they’ll employ.ĭistended beasts that burst Upon passing, roaring hulks that bill a fee want rhinos, and shrieking witches which teleport upon the battle are only a couple of those critters you’ll face. There are just eight unique creatures in left 4 dead 2 – famous from the match’s parlance because”special infected” – and also their design is really gruesome even with contemporary graphic standards. And though the zombie milieu might not be fresh nowadays, the critters themselves continue to be characteristically different. You play left 4 dead 2 with swimmers seeking to just live in the aftermath of an undead apocalypse. ![]() Left 4 Dead 2 goes hard into zombie aesthetics, which have come to dominate the entire entertainment arena. That is thanks in big role To the thoughtful monster design in the office. Quite a few imitators have tried to enlarge on such a routine however, none have been able to achieve success quite also. And though the images could be revealing how old they are now, the formula continues to be new and fresh. ![]() Probably Perhaps one of the very defining combined shooters ever sold, plus it succeeds in building liberally on this formula and shine some feeble areas without destroying the magic balance which did the initial job. Mind collecting all necessary product logs before sending the request. To submit a support request, select Help | Contact Support from the AppCode main menu. To report a bug or suggest a new feature, add an issue in YouTrack: log in to your JetBrains account and click New Issue. How do I leave feedback or submit bugs and support requests? ![]() Check out all the special offers on our website or contact our sales support for more details. In some cases, AppCode, along with other JetBrains desktop products, can be used for free or at 50% discount, for example, for university students, open source contributors, and startups. However, you can try AppCode by using a free 30-day trial or Early Access Program (pre-release) versions as long as they are available. Also, running and debugging is a pain then.AppCode FAQ General Is there a free AppCode version? I've tried to set up VSCode as a Xcode alternative, but the Swift sourcekit-lsp is way worse than Rust-Analyzer. Also, when I save the code is formatted based on the guidelines, which is a godsend. VSCode is faster, smoother, auto completion works much more reliably, refactoring works great, the IDE already shows errors while I'm typing or right after I've saved. I also work on a sizeable Rust project (60k loc), and while Rust analyser needs longer for the initial indexing of the project, everything else after that is way better than Xcode. There's obviously more, but here's the thing. I'd like to have auto-reformat on save as a plugin, way better vim bindings (I mean, we finally got vim bindings but they're awful), bookmarks (I sometimes use disabled debugger breakpoints as bookmarks, but that's not really a feature). That's a terrible feedback loop.Īpart from that, there's no useful plugin / extension interface. Then it compiles, it fails, it needs another 5sec, and then the error message appears. Not while I'm typing, not when I've saved, only once I started compiling. Sometimes Xcode needs forever to figure out that there's an error in something I wrote. SwiftUI preview still doesn't work properly in many cases Its still the case that compiler error messages are completely in the wrong place for complex type errors Sometimes the unit test buttons disappear (the ones that appear next to the unit test function name), which means I can't run individual tests anymore. Compare that to the speed of VSCode, where all interactions are super fast Searching for things, typing, the editor. Change one package file, and Xcode needs 2min (where the UI is unresponsive) to reload all the packages and do some weird calculations Swift Package Manager integration is awful. Weird compile errors that disappear when I clean the build folder They stay there until I restart Xcode and clean the build folder The app compiles but Xcode still lists 3-4 compile errors in the sidebar. I've switched to using text based search for all things) Symbol search doesn't work (this literally never works. ![]() ![]() Xcode doesn't know the struct or class when I try to find information on it) ![]() Auto completion completely doesn't work in some files I'm working on multiple complex projects in the 100k loc to 500k loc range and here're some things that happen way too often: You might be lucky that your project doesn't have a certain complexity. ![]() It’s the ultimate strategy for any solitaire card game variant - reveal as many new cards as you can as early as possible. Note that you may want to change it up ever so slightly to account for twice as many cards. If you’re familiar with regular Klondike solitaire and find yourself winning more games than you lose, then your regular strategy should work. What is the best strategy for winning Double Klondike Solitaire ? If you can’t make a move, use the waste pile : this opens up more moves and allows you to continue the game Stock and waste piles are included: use these for extra cards and to dump cards when you can’t make a move Only kings can move into empty tableau spaces. But to move a group of cards, these must be ordered by rank. You can move cards one by one or multiple at one time. Tableaus build in descending order, alternating color between red and black: the top card of each pile can be played on the foundation piles Regular Klondike rules apply to double Klondike solitaire, but nonetheless, the rules are as follows:įoundations must be built up in ascending suit order: e.g., Ace of Diamonds to King of Diamonds This version of the game is classic Klondike, but with twice as many cards, making it a little easier. For example, when you start a foundation pile with the ace of diamonds, you’ll finish it with the king of diamonds. Although, in the double version, there are more cards, so there are twice as many cards to move.Īll foundation piles must start with an ace and finish with a king, built in ascending suit order. The objective of double Klondike solitaire is the same as all other variants - move all cards to the foundation piles in the correct order to win. If you’re playing with real cards, be sure to remove the jokers from both decks before dealing a new game. If you’re playing an online game of solitaire, then the game is set up for you. The remaining cards are placed in the stock pile - these can be used throughout the game when you run out of moves. The top card of each tableau should be placed face-up with the remaining playing cards face down. The first tableau pile begins with one card, the second pile has two, the third three, and so on until you reach nine total piles. Unlike regular Klondike solitaire, where there are seven columns (known as the tableau), there are now nine columns. Waste pile : As you empty the stock pile, the cards you don’t place in the tableau make up the waste pile. Stock pile : This pile is the remainder of the deck that hasn’t gone into the tableau piles. They are shuffled and dealt before the card game starts. Tableau piles : These are the workable piles on the table. You’ll build them up as you go, usually starting with aces. How to Play Double Klondike Solitaire Types of Pilesįoundation piles : These are the empty piles at the beginning of the game. ![]() The hard plastic mic is built into the housing of the left earcup, so it sits flush when flipped up into mute position. The Stealth 700 Gen 2 has a slimmer version of Turtle Beach’s usual built-in microphone. (As someone who likes to put on a podcast while playing some games, this was a huge revelation for me). This allows you to adjust audio levels on the fly while playing, but also lets you listen to a podcast or take a call on your phone while listening to your Xbox audio at the same time. Better yet, you can pair it with a Bluetooth device and an Xbox simultaneously. It’s much easier to pair the headset with a PC, and you can pair it with other devices, like your phone. Bluetooth greatly expands the headset’s utility. You just press the pairing button on the console, then the button on the headset, and they pair. Both headsets have the Xbox pairing, which makes syncing your headset with an Xbox extremely convenient. One of the biggest differences between the Stealth 600 Gen 2 and Stealth 700 Gen 2 is having access to both the Xbox pairing protocol and Bluetooth. You can change the secondary volume wheel and the mode button inputs to adjust other functions using the Turtle Beach Audio Hub app, which is a nice added bit of customization for a console headset. A “mode” button to toggle Superhuman hearing, Turtle Beach’s performance audio mode, a power button, Bluetooth and Xbox protocol pairing buttons, and a USB-C port for charging. From top to bottom, you have: Two volume wheels, one for speaker volume and one for chat. There are a lot of controls stacked along the back edge of the Stealth 700’s left earcup. A 20-hour charge is on the high side of average for a gaming headset, but that should be more than enough for most players, so long as you keep a charging solution handy to top it off between sessions. Anecdotally, I found the headset lasted through about three days of regular use on average, even when regularly pairing and unpairing with my smartphone. According to Turtle Beach, the Stealth 700 Gen 2 should last through 20 hours on a single charge, up from just 10 hours per charge on the original. And thanks to a much longer-lasting battery, you can wear the Stealth 700 Gen 2 through lots of long gameplay sessions. Normally, mesh covering on earcups is a red flag for me – it’s often scratchy and heats up quickly: The Stealth 700 Gen 2 only started to feel hot after long gameplay sessions, which I found impressive. ![]() The cups also feature a thick layer of cooling memory foam padding, coated with leatherette on the sides and a smooth mesh over the front. The cups feel like they conform to the shape of your ears, but also feel quite roomy. The entire headset is slightly larger than its budget-friendly counterpart, but there’s an outsized difference in the earcups, where it counts. One of the big advantages of the Stealth 700 Gen 2 – over both its predecessor and the Stealth 600 Gen 2 – is comfort. You may also notice the issue when rotating the Stealth 700 Gen 2’s earcups on their hinges, which allow the cups to lie flat on your chest or on a table. Like the Stealth 600 Gen 2, the band lines up with the front of the cans, rather than the center, which can make it feel like you’re putting the gaming headset on backward when you wear them the first time. The top band is made of plastic with a steel frame, which becomes visible when you adjust the cans. Though the plastic band is slightly larger and features a steel frame, the Stealth 700 Gen 2 features the same rotating hinges as the Stealth 600 Gen 2, and the same shaped earcups designed to hug your ears. Answer See ResultsEven with all its changes, though, the Stealth 700 Gen 2 is still a more feature-rich version of the Stealth 600 Gen 2, and the last generation of Turtle Beach’s Stealth headsets. ![]() Only recent technological developments, such as in vitro expansion of single cells into colonies 13, 14, microdissection of histological units 8, 15, single-cell sequencing 16, 17 or single-molecule sequencing 18, are beginning to enable the study of somatic mutation in normal tissues. Directly studying somatic mutations in normal tissues has been challenging owing to the difficulty of detecting mutations present in single cells or small clones in a tissue. ![]() They underpin the development of cancer 9 and, for decades, have been speculated to contribute to ageing 10, 11, 12. Somatic mutations accumulate in healthy cells throughout life. ![]() These data unveil common mutational processes across mammals, and suggest that somatic mutation rates are evolutionarily constrained and may be a contributing factor in ageing. Despite widely different life histories among the species we examined-including variation of around 30-fold in lifespan and around 40,000-fold in body mass-the somatic mutation burden at the end of lifespan varied only by a factor of around 3. Notably, the somatic mutation rate per year varied greatly across species and exhibited a strong inverse relationship with species lifespan, with no other life-history trait studied showing a comparable association. With some differences, mutational signatures in other species resembled those described in humans 8, although the relative contribution of each signature varied across species. We found that somatic mutagenesis was dominated by seemingly endogenous mutational processes in all species, including 5-methylcytosine deamination and oxidative damage. Here we performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somatic mutation across 16 mammalian species. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the evolution of somatic mutation rates and their role in cancer and ageing. The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans 1, 2, 3, 4, 5, 6, 7. Nature volume 604, pages 517–524 ( 2022) Cite this article Somatic mutation rates scale with lifespan across mammals |
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